About Polynucleotides – Polynucleotide Injections

Polynucleotide Injections

Your skin is a canvas that deserves the best

There is no one-size-fits-all approach when it comes to aesthetic treatments. It is time to give your skin the personalised treatment it deserves. Polynucleotides trigger the body’s natural collagen1 production processes leading to more radiant, rejuvenated skin.

PolyPhil™ (formerly PhilArt) is a polynucleotide-based treatment that invigorates your look. PolyPhil™  stimulates the production of collagen1 and elastin, which help to improve the texture and elasticity of the skin3. Polynucleotides also enhance the skin’s natural ability to retain moisture, resulting in a more hydrated and youthful appearance.3

Understanding age-related skin changes

Age-related changes can occur in all layers of the skin leading to visibly decreased skin quality. Ageing is often accompanied by a significant decrease in superficial midface fat tissue, volume and thickness. In addition, the loss of bony support leads to a decrease in volume and sagging.

What are Skin Boosters?

Skin boosters are a new, popular class of injectable treatments for skin rejuvenation. Skin booster injections are most frequently applied to enhance the skin of the midface, lower face, décolletage, and hands. PolyPhil™ is a skin booster that uses the power of polynucleotides to improve skin quality.

Polynucleotides are chains of nucleotides that form the basis of DNA. In aesthetics, these chains are used to trigger the body’s natural healing responses for skin rejuvenation. PolyPhil™ uses polynucleotides derived from fresh-water trout, bred in highly controlled European fish farms allowing for a consistently safe and effective product.

Unlock the full potential of your skin with Polynucleotides

PolyPhil™ has a safe and effective formula that is backed by extensive clinical data, showing improvements in skin hydration, texture, and rejuvenation.

  • Safe3: PolyPhil™ is well tolerated by patients and has low rates of side effects
  • Enhanced skin hydration2: PolyPhil™ improves the hydration2 levels of the skin, leading to a more radiant and healthy-looking complexion.
  • Improved skin texture3: PolyPhil™ improves the texture of the skin, making it look and feel softer and smoother.
  • Reduction in fine lines4: PolyPhil™ reduces the appearance of fine lines particularly around the eyes and mouth.
  • Skin rejuvenation3: PolyPhil™ stimulates the production of collagen1 and elastin in the skin, leading to a smoother, more youthful complexion.

References:
1 Collangelo MT. Govoni P, Beletti s, Squadrito F, Guizzardi S,Galli C. Polynucleotide biogel enchances tissue repair, matrix desposition and organization. J. of Biological Regulators & Homeostatic Agents. 2021;Vol35(1):355-362.
2 Bartoletti E, Cavallini M, Maioli L, Massirone A, Palmieri IP, Papagni M et al. Introduction to Polynucleotides Highly Purified Technology. Aesthetic Medicine.2020 Oct-Dec;Vol.7(1):43-47.
3 Cavallini M, Papagni M. Long Chain Polynucleotides Gel and Skin Biorevitalization. International Journal of Plastic Dermatology-ISPLAD. 2007; 3(3): 27-32
4 Araco A, Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars. Aesthet Surg J. 2021 Jun 14;41(7):NP866-NP874. doi: 10.1093/asj/sjab125. PMID: 33755110.
5 Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021 Mar;20(3): 922-928. doi: 10.1111/jocd.13679. Epub 2020 Sep 21. PMID: 32799391; PMCID: PMC7984045.
6 Massirone A. Polynucleotides Highly Purified Technology and the face skin, a history of innovative skin priming. Aesthetic Medicine.2021 Jan-Mar;Vol.7(1): 25-40.

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